If the calculated OXYCONTIN full day by day dosage is less than 20 mg, there isn't any safe strength for conversion and don't initiate OXYCONTIN.
Misuse and abuse of OXYCONTIN will increase possibility of overdose, which may produce central anxious process and respiratory melancholy, hypotension, seizures, and Dying. The chance is improved with concurrent abuse of OXYCONTIN with Liquor and/or other CNS depressants.
To decreased your possibility, your health care provider should have you take the smallest dose of oxycodone that works, and choose it with the shortest achievable time. See also Ways to Use area for more information about dependancy.
The chance for extreme breathing troubles is increased when you start this medication and after a dose improve, or if you're taking the wrong dose/toughness. Taking this medication with alcohol or other medication that may cause drowsiness or respiration difficulties may well lead to really severe Unwanted side effects, which include Dying. Also, other drugs can have an impact on the removing of oxycodone from the human body, which can have an affect on how oxycodone will work.
Opioid use improves the danger of CSA in a dose-dependent manner. In patients who present with CSA, look at lowering the opioid dosage making use of most effective practices for opioid taper [see DOSAGE AND ADMINISTRATION].
Also, success from one research have revealed a hyperlink between certain here start defects and the use of opioids by pregnant Girls.
Lethal side effects can happen if you use opioid medicine with Liquor, or with other prescription drugs that cause drowsiness or sluggish your respiration.
This drug passes into breast milk and might have unwanted consequences on a nursing toddler. Notify the medical professional right away if your little one develops unconventional sleepiness, problem feeding, or hassle breathing. Talk to your doctor in advance of breastfeeding.
Reduced human body fat was identified in the course of lactation and also the get more info early article-weaning period in pups nursed by mothers supplied the best dose utilized (six mg/kg/working day, equivalent to an Grownup human dose of 60 mg/day, on the mg/m2 basis). Even so, human body excess weight of those pups recovered.
The dosage is based on your own health-related situation and reaction to treatment method. Will not boost your dose, take the medication additional normally, or consider it for an extended time than prescribed. Properly prevent the medication when so directed.
If concomitant use is more info warranted, commonly evaluate the client, notably through treatment method initiation and dose adjustment. Discontinue OXYCONTIN if serotonin syndrome is suspected.
Opioid analgesics, such as OXYCONTIN, can lengthen labor by way of actions which temporarily decrease the strength, length, and frequency of uterine contractions. Nonetheless, this impact is not really dependable and could be offset by a heightened rate of cervical dilatation, which tends to shorten labor. Observe neonates subjected to opioid analgesics throughout labor for indications of extra sedation and respiratory depression.
Interactions with medicines called CYP450 3A4 inhibitors may possibly bring about a rise in oxycodone plasma concentrations, which could raise or prolong adverse reactions and may lead to most likely fatal respiratory depression.
Get in touch with local condition Expert licensing board or state-managed substances authority for information on how to circumvent and detect abuse or diversion of this product.